
姓 名:毛东海 性 别:男
职 务:主任
职 称:研究员 学 历:博士
电 话: 通讯地址:湖南省长沙市芙蓉区远大二路644号
传 真: 邮政编码:
电子邮件:donghai.mao@isa.ac.cn
博士,研究员,博士生导师
国家高层次人才特殊支持计划青年拔尖人才 | 中国科学院青年创新促进会会员湖南省自然科学基金杰出青年基金获得者 | 长沙·中国隆平芯谷青年科技创新人才
2004年获华中农业大学农学学士学位(优秀毕业生);2010年获华中农业大学理学博士学位(作物遗传改良全国重点实验室)。2010年起受聘于中国科学院亚热带农业生态研究所,现任主任、研究员、博士生导师。主要从事植物环境适应与遗传改良研究,其中在南方籼稻低温韧性遗传改良方向上取得系列成果:已发掘低温韧性基因HAN1、HAN2、CTP1等,系统解析了多种植物激素介导的低温韧性形成的分子遗传机制。目前,以第一或通讯作者在PNAS、Nature Communications、Plant Biotechnology Journal、Plant Journal等期刊发表论文20余篇,申请发明专利8项,以第一完成人获得2024年度湖南省自然科学二等奖(温带粳稻与其野生稻适应低温环境的分子遗传基础)。
1.岳麓山实验室种业专项(面上项目),水稻耐冷QTL簇的发掘与利用,2025-2028,主持;
2.国家高层次人才特殊支持计划(青年拔尖):水稻耐气候逆境基因挖掘与利用,2022-2025,主持;
3.农业农村部科技创新2030重大项目(课题):资源高效利用新基因挖掘与育种价值评价,2023-2025,主持;
4.湖南省自然科学基金委(杰出青年):水稻第11号染色体耐冷QTL簇的基因克隆与协同进化分析,2021-2023,主持;
5.国家自然科学基金(面上):水稻苗期耐冷基因HAN2的克隆与功能机理分析,2021-2024,主持;
6.中国科学院青年创新促进会(会员):茉莉酸调控水稻耐冷性的分子机制,2019-2022,主持;
7.湖南省重点研发计划(国际合作):水稻淹涝适应性的遗传基础及其栽培轻简化应用,2020-2022,主持;
8.海南省崖州湾种子实验室(揭榜挂帅):高温影响水稻分蘖形成的表观遗传机制,2021-2022,主持;
9.国家自然科学基金(面上):水稻苗期耐冷基因qCTS11的克隆与功能分析,2014-2017,主持;
10.国家自然科学基金(青年):东乡野生稻越冬耐寒性的遗传分析,2012-2014,主持;
11.中国科学院亚热带农业生态研究所青年前沿领域部署项目:水稻亚种间低温响应转录组学差异分析,2011-2012,主持。
1.Liu P, Huang X, Xia Y, Cui Y, Mao D. OsCTP1 negatively regulates seedling cold tolerance in rice. Mol Breed.2026 Apr 13;46(4):35.
2.Zhao L, Wang J, Ji X, Yang M, Chen Q, Wei X, Mao D, Xie G, Wang L. The C2 domain-containing and Ca2+-binding protein OsERG1 interferes with OsPYL10-OsPP2C09 module to negatively regulate the chilling tolerance in rice. Plant J. 2026 Mar;125(5):e70750.
3.Cui Y, Huang L, Liu P, Wang X, Wu B, Tan Y, Huang X, Hu X, He Z, Xia Y, Li Z, Zhang W, Tang W, Xing Y, Chen C, Mao D. Suppressing an auxin efflux transporter enhances rice adaptation to temperate habitats. Nat Commun. 2025 May; 16:4100.
4.Liu P, Sun L, Zhang Y, Tan Y, Zhu Y, Peng C, Wang J, Yan H, Mao D, Liang G, Liang G, Li X, Liang Y, Wang F, He Z, Tang W, Huang D, Chen C. The metal tolerance protein OsMTP11 facilitates cadmium sequestration in the vacuoles of leaf vascular cells for restricting its translocation into rice grains. Mol Plant. 2024 Nov;17(11):1733-1752.
5.Liu T, Huang L, Liu P, Cui C, Chen C, Mao D. The RISE Method Based on Rare Allele Infusion and Sanger Sequencing Estimation: A Simple, Cheap, and Efficient Method for Detecting Transgenic Copy Number in Rice. Rice Sci. 2024, 31(5): 499−502.
6.Wu B, Meng J, Liu H, Mao D, Yin H, Zhang Z, Zhou X, Zhang B, Sherif A, Liu H, Li X, Xiao J, Yan W, Wang L, Li X, Chen W, Xie W, Yin P, Zhang Q, Xing Y. Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice. Nat Genet. 2023 Aug; 55(8):1381-1389.
7.Mao D, Tao S, Li X, Gao D, Tang M, Liu C, Wu D, Bai L, He Z, Wang X, Yang L, Zhu Y, Zhang D, Zhang W, Chen C. The Harbinger transposon-derived gene PANDA epigenetically coordinates panicle number and grain size in rice. Plant Biotechnol J. 2022 Jun; 20(6):1154-1166.
8.Li L, Mao D, Sun L, Wang R, Tan L, Zhu Y, Huang H, Peng C, Zhao Y, Wang J, Huang D, Chen C. CF1 reduces grain-cadmium levels in rice (Oryza sativa). Plant J. 2022 Jun;110(5):1305-1318.
9.Li X, Xiang F, Zhang W, Yan J, Li X, Zhong M, Yang P, Chen C, Liu X, Mao D, Zhao X. Characterization and fine mapping of a new dwarf mutant in Brassica napus. BMC Plant Biol. 2021 Feb; 21(1):117.
10.Tan Y, Sun L, Song Q, Mao D, Zhou J, Jiang Y, Wang J, Fan T, Zhu Q, Huang D, Xiao H, Chen C. Genetic architecture of subspecies divergence in trace mineral accumulation and elemental correlations in the rice grain. Theor Appl Genet. 2020 Feb;133(2):529-545.
11.Yu Y, Hu X, Zhu Y, Mao D. Re-evaluation of the rice ‘Green Revolution’ gene: the weak allele SD1-EQ from japonica rice may be beneficial for super indica rice breeding in the post-Green Revolution era. Mol Breed. 2020. 40:84.
12.Mao D, Xin Y, Tan Y, Hu X, Bai J, Liu ZY, Yu Y, Li L, Peng C, Fan T, Zhu Y, Guo YL, Wang S, Lu D, Xing Y, Yuan L, Chen C. Natural variation in the HAN1 gene confers chilling tolerance in rice and allowed adaptation to a temperate climate. Proc Natl Acad Sci U S A. 2019 Feb;116(9):3494-3501.
13.Li L, Chen H, Mao D. Pyramiding of rapid germination loci from Oryza Sativa cultivar ‘Xeqingzao B’ and cold tolerance loci from Dongxiang wild rice to increase climate resilience of cultivated rice. Mol Breed. 2019. 39:85.
14.Li G, Jin J, Zhou Y, Bai X, Mao D, Tan C, Wang G, Ouyang Y. Genome-wide dissection of segregation distortion using multiple inter-subspecific crosses in rice. Sci China Life Sci. 2019 Apr; 62(4):507-516.
15.Li L, Mao D. Deployment of cold tolerance loci from Oryza sativa ssp. Japonica cv. ‘Nipponbare’ in a high-yielding Indica rice cultivar 93-11. Plant Breed. 2018, 137(4) 553-560.
16.Li D, Huang Z, Song S, Xin Y, Mao D, Lv Q, Zhou M, Tian D, Tang M, Wu Q, Liu X, Chen T, Song X, Fu X, Zhao B, Liang C, Li A, Liu G, Li S, Hu S, Cao X, Yu J, Yuan L, Chen C, Zhu L. Integrated analysis of phenome, genome, and transcriptome of hybrid rice uncovered multiple heterosis-related loci for yield increase. Proc Natl Acad Sci U S A. 2016 Oct;113(41): E6026-E6035.
17.Tang M, Zhou C, Meng L, Mao D, Peng C, Zhu Y, Huang D, Tan Z, Chen C, Liu C, Zhang D. Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism. J Genet Genomics. 2016 Nov 20;43(11):673-676.
18.Bai X, Huang Y, Mao D, Wen M, Zhang L, Xing Y. Regulatory role of FZP in the determination of panicle branching and spikelet formation in rice. Sci Rep. 2016 Jan 8;6:19022.
19.Mao D, Yu L, Chen D, Li L, Zhu Y, Xiao Y, Zhang D, Chen C. Multiple cold resistance loci confer the high cold tolerance adaptation of Dongxiang wild rice (Oryza rufipogon) to its high-latitude habitat. Theor Appl Genet. 2015 Jul;128(7):1359-71.
20.Zhang L, Mao D, Xing F, Bai X, Zhao H, Yao W, Li G, Xie W, Xing Y. Loss of function of OsMADS3 via the insertion of a novel retrotransposon leads to recessive male sterility in rice (Oryza sativa). Plant Sci. 2015 Sep; 238:188-97.
21.Wu B, Mao D, Liu T, Li Z, Xing Y. Two quantitative trait loci for grain yield and plant height on chromosome 3 are tightly linked in coupling phase in rice. Mol Breed. 2015, 35: 156.
22.Yao W, Sun L, Zhou H, Yang F, Mao D, Wang J, Chen L, Zhang G, Dai J, Xiao G, Chen C. Additive, dominant parental effects control the inheritance of grain cadmium accumulation in hybrid rice. Mol Breed. 2015, 35: 39.
23.Tang M, Mao D, Xu L, Li D, Song S, Chen C. Integrated analysis of miRNA and mRNA expression profiles in response to Cd exposure in rice seedlings. BMC Genomics. 2014 Oct;15(1):835.
24.Yang C, Li D, Mao D, Liu X, Ji C, Li X, Zhao X, Cheng Z, Chen C, Zhu L. Overexpression of microRNA319 impacts leaf morphogenesis and leads to enhanced cold tolerance in rice (Oryza sativa L.). Plant Cell Environ. 2013 Dec; 36(12):2207-18.
25.Mao D, Chen C. Colinearity and similar expression pattern of rice DREB1s reveal their functional conservation in the cold-responsive pathway. PLoS One. 2012; 7(10):e47275.
26.Mao D, Yu H, Liu T, Yang G, Xing Y. Two complementary recessive genes in duplicated segments control etiolation in rice. Theor Appl Genet. 2011 Feb;122(2):373-83.
27.Mao D, Liu T, Xu C, Li X, Xing Y. Epistasis and complementary gene action adequately account for the genetic bases of transgressive segregation of kilo grain weight in rice. Euphytica. 2011; 180(2):261-271.